Insulin Resistance in Children and the role of Endocrine-Disrupting Chemicals: Taking Stock of the Situation

The prevalence of non-communicable diseases, which insulin resistance is a major constituent, among the pediatric population exponentially increasing worldwide; this causing significant health burden, making understanding basis phenomenon an issue primary importance. During last decades, we also observed that exposure to endocrine-disrupting chemicals becoming more and common; has led researchers investigate mechanism action define role those substances in interfering with human metabolism hormonal balance, especially at young age. We reviewed literature on prospective, epidemiological, cross-sectional studies have shown link between pesticides, polychlorinated biphenyls, bisphenol A, phthalates, aromatic polycyclic hydrocarbons, or dioxins resistance; strength associations varies biomonitoring helped defining these chemicals. number prospective children even adults still low heterogenous, still, evidence Endocrine disruptors might be involved development related diseases accumulating. This review aims analyze latest findings linking perspective taking cue for conducting new identifying most concerning exposures, order guide future risk assessment policy aimed limit negative consequences endocrine disrupting chemical exposure.